Role of Tab Parijataka in the management of sheetpurvak jwara ( Malaria)

Title:- Role of  Tab Parijataka in the management of sheetpurvak jwara ( Malaria)

Dr. Aparna V. Deshpande had submitted her dissertation to Pune University for the P. G. degree M.D. (Kaya Chikitsa) in the year 1999. Her guide was Prof. Dr. P. H. Kulkarni & Research center was Tilak Ayurved Mahavidyalaya, Pune, (M.S.) India.

          Dr. Aparna V. Deshpande in her research work tried to evaluate role of parijataka guti in the management of sheetpurvak jwara.

          Patients were treated with parijataka guti in the dose of 1.5 gm with lukewarm water three times a day at 8 am, 2 pm & 8 pm. Duration of the treatment was 7 days.

          Temperature chart of the patients was maintained every two hourly and as per need.

          For clinical study 50 patients were selected.

Criteria for assessment of cure was as follows-

1) Decreased frequency of rigors/chills,

2) Decreased temperature

3) Sweating

4) Agnivaradhana.

          Animal experiments were also carried out to study anti-inflammatory activity of parijataka guti.

Methods used are as follows-

A)  Rat paw edema – An irritant is injected into subcutaneous tissue on the planter aspects to rat hind paw to produce inflammation. The resultant swelling is measured by plethysmometer at different intervals. Formaldehyde carageenan, yeast, egg white, kaolin is some of the common irritant used. ( winter et al 1962 )

B)   Cotton pellet granuloma method – Sterile cotton pellets of known weight are implanted into the subcutaneous tissue. The animals are dosed orally, daily for seven days. The pellets are then removed with the surrounding granulation tissue and dried overnight till constant weight (Satoskar & Bhandarkar, 1993).

 Standard operating procedure for plethysmometer 7140 was adopted   calibration of the instrument was carried out with the help of volume probes.

The percentage inhibition was calculated by using the formula.

% inhibition = [1 – Vd – Vp/Vc-Vp ] x 100

                                

Vd – Vp = Difference in paw volume after carageenan injection & initial paw volume for drug treated animal.

Vc – Vp = Difference in paw volume after carageenan injection & initial paw volume for control animals.

          The study was concluded as follows- 

When Tab Parijataka was given  in the dose of 1.5 gm TDS ,with lukewarm water for 7 days ,was found useful in the patients of Malaria.

Chi square test & T. Test are proved to be significant 0.5% probability i.e. 95% people can be cured. But actually case studies show 80% patients cured completely while 12% patients got partial relief & 8% of patients did not responded to the therapy.

Parijataka guti is found to be more effective mainly on pranavaha srotas and annavaha srotas.