The study of efficiency of shashilekha vati in shivtra vyadhi( Leucoderma)

Title: The study of efficiency of shashilekha vati in shivtra vyadhi( Leucoderma)

                   Dr. Kavita W. Lanjewar had submitted her dissertation to the Pune University in 2006 for the P.G. degree M.D. (Kaya Chikitsa). Her guide was Dr. Sadanand V. Deshpande & Research center was Tilak Ayurved Mahavidyalaya, Pune (M.S.) India.

          Dr. Lanjewar in her research tried to study the efficiency of Shashilekha vati in leukoderma. Shashilekha tablet was prepared as per the reference from the book Yogaratnakar in the topic of kushtha Chikitsa. This tablet mainly contains mercury, sulpher, Bakuchi, copper. Tablet was prepared weighing 125 mg each. Chronic animal toxicity study was done at National toxicity center (NTC, Pune)

          For clinical trials study design was randomized single blind controlled two groups of leukoderma were prepared, each containing 30 patients.

 Group A was given Shashilekha vati 125 mg. tds with Bakuchi taila & honey as a vehicle (Anupana).

Group B was given Yahtimadhu (Glyceriza Glabra) tablet 125 mg tds was given with lukewarm water. Treatment period was minimum 49 days with regular weekly follow up.

          Efficiency parameters were

i)                   Re pigmentation, ii) measurement of lesion, iii) Visual analogue scale.

Regimentation – classified into four types

a)     Marginal – when predominant repigmentaion was from the borders of patches.

b)    Perifollicular – When predominant repigmentaion was follicular.

c)     Diffused – When there is generalized darkening across the patches of leukoderma.

d)    Combined – Which does not fit into any above single type or when more than one pattern continued to the pigmentary process.

II) Re-pigmentation was recorded as Grade 0 = No change , Grade 1 = minor change ( 25%) , Grade 2 = moderate change ( 50%) , Grade 3 = marked  change ( 75%) , Grade 4 = Complete re pigmentation  ( 100%) .

III) Measurement of area of lesion – The patches was traced on the paper with pencil. These tracings were kept on graph paper & again these tracings of patches were traced on graph paper. Total squares of graph paper covered by tracing were counted & total area was calculated. The photographic records were kept.

IV) Visual analog scale – This was used to assess two parameters mentioned in Ayurvedic text, namely itching (Kandu) & burning sensation (Daha).

 Above research work is concluded as follows –

In Patients receiving Tab Shashilekha 125 mg. tds with Honey  & Bakuchi taila externally ,

i)                   There  was significant re pigmentation in treated lesion & reduction in total area of lesion.

ii)                Control group showed very poor result as compared to treated group.

iii)              It is observed that out of 30 patterns in drug group, which were taking shashilekha tablet , 19 patients had marked to complete

 repigmentation, 7  patients had marked repigmentation, 3  patients had moderate repigmentation and only 1 patient had minimum

repigmentation.